Research

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Danish Nano Safety Centre has organized its activities in a main project, involving 4 research themes:

  • Improved exposure assessment.
  • Improved toxicological studies.
  • Improved knowledge of the underlying mechanisms of action of the adverse effects.
  • Better models for risk assessment and risk management.

The 4 themes include a total of 14 sub-projects, 5 of which are PhD projects.

Theme 1. Exposure and characterisation

1.1. Development of on-line measurements of nanoparticle aerosols and exposure
measurements in the working environment
1.2. Exposure and emission measurements of nanoparticles
1.3. Physical/chemical characterisation of nanoparticles

Theme 2. Nanoparticle toxicology

2.1. Screening of toxic effects of nanomaterials
2.2. Carbon nanotubes: inflammation and genotoxicity in the lung and other organs
2.3. Serum Amyloid A as a biomarker for risk assessment for nanoparticle-induced
plaque progression
2.4. Effects of nanoparticles on reproduction and fetal development
2.5. Model of pulmonary deposition for nanoparticles in murine airways

Theme 3. Mechanisms of action

3.1. Toxicological effects of hepatic accumulation of nanoparticles
3.2. Interaction between nanoparticles and lung surfactant proteins
3.3. In vivo and in vitro effects of interaction between nanoparticles and lung
surfactants
3.4. Exposure to nanoparticles and effects on gene expression

Theme 4. Exposure assessment, risk assessment and risk management

4.1. Risk assessment and risk management of nanomaterials
4.2. Qualitative and quantitative methods for exposure assessment for
nanomaterials

In several of the subprojects the Centre corporate closely with international researchers from the following institutions:

The Centre’s research is complemented by a series of research projects on nano particles funded through the EU Framework Programme that The National Research Centre for the Working Environment, NRCWE, participates in. The largest of the projects have more than 20 partners.